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Grape Seed Extract: A Hidden Gem for Antioxidant Support

Grape seed extract (GSE), derived from the seeds of grapes, is gaining recognition as a potent ingredient in the health and wellness industry. Packed with powerful antioxidants, including proanthocyanidins, this natural extract offers numerous health benefits. From reducing inflammation to supporting cardiovascular health, grape seed extract is truly a hidden gem.

Benefits of Grape Seed Extract

1. Rich in Antioxidants

Grape seed extract is a powerhouse of antioxidants, particularly proanthocyanidins. They have a higher antioxidant activity when compared to other well-known antioxidants like vitamin C, vitamin E, and carotene. These compounds help neutralize harmful free radicals in the body, protecting cells from damage caused by oxidative stress. This protective effect supports overall health and helps reduce the risk of chronic diseases. (1,2)

2. Promotes Cardiovascular Health

Essential fatty acids, especially linoleic acid from the omega-6 family, are abundant in grape seeds. It aids in controlling blood cholesterol levels overall, especially low-density lipoproteins (LDL), commonly referred to as “bad cholesterol.” In fact, the development of atherosclerosis is caused by LDL cholesterol. Thus, omega-6 from grape seed extract can assist blood pressure regulation, lower inflammation, and help control bad cholesterol levels. Together with dietary interventions, such as preventing arteriosclerosis, which is the hardening of the arteries, these cumulative effects can help maintain a healthy cardiovascular system and lower the chance of developing cardiovascular diseases. (3)

3. Anti-Inflammatory Properties

Grape seed extract contains proanthocyanidins, which may lessen inflammation by controlling inflammatory pathways and lowering the buildup of nitric oxide and pro-inflammatory cytokines. Chronic inflammation is a root cause of many health issues, including arthritis and heart disease. Grape seed extract contains bioactive compounds that can help reduce inflammation, promoting overall wellness and joint health. In addition to this, Grape seed extract may aid with wound healing, eye strain, and chronic venous insufficiency. (4)

4. Enhances Skin Health

The antioxidant properties of grape seed extract also extend to skin health. By protecting the skin from damage caused by UV rays and pollution, it helps maintain elasticity and reduces signs of aging, such as wrinkles and fine lines. The anti-inflammatory properties of grape seed extract help significantly improve skin barrier function. Grape seed extract contains resveratrol which helps support collagen content in the skin, promoting better aging. (3,5)

5. Supports Cognitive Function

Emerging research indicates that grape seed extract may support brain health by protecting neurons from oxidative stress and improving blood flow to the brain. This makes it a promising ingredient for cognitive health and memory support. It is believed that flavonoids’ anti-inflammatory and antioxidant qualities can postpone or lessen the onset of neurodegenerative illnesses like Alzheimer’s disease. (6)

6. Aids in Weight Management

Grape seed extract has been linked to supporting metabolism and delaying fat absorption, which suppresses hunger. This could help those who are trying to reduce their body weight or who need to consume less fat for other health-related reasons. The grape seed extract’s mode of action involved inhibiting both the pancreatic enzyme lipase and the enzyme lipoprotein lipase, which hydrolyzes triglycerides from plasma lipoproteins. This may help aid in weight management when combined with a balanced diet and regular exercise. (7, 8)

7. Immune Health

The immune-boosting properties of grape seed extract are attributed to its ability to combat oxidative stress, which can weaken the immune system. The tannins included in grape seed extract have antimutagenic and antioxidant properties. As a result, grape seed extract may shield other tissues, including the lining of blood vessels, from harm. Extract from grape seeds may offer protection against oxidized LDLs, free radicals, and other detrimental aspects of metabolism. It is claimed that extract from grape seeds lowers histamine production. This could make nasal allergies less severe. Additionally, it might lessen the early deterioration of vitamin C.  Regular intake can help strengthen the body’s defense mechanisms. (9,10)

Final Thoughts

Adaptogens are natural substances that help the body adapt to stress and restore balance. Grape seed extract, with its potent antioxidant and anti-inflammatory properties, functions as an adaptogen by helping the body manage oxidative and environmental stress. It supports homeostasis, ensuring that various physiological processes remain balanced even during times of stress. Grape seed extract is a natural treasure with an array of health benefits, from enhancing cardiovascular health to promoting glowing skin and supporting stress management. Its adaptability and potency as an adaptogen make it a valuable addition to any wellness routine. Ruokamill’s ProBlend+ for Adults incorporates grape seed extract as an adaptogen, to ensure that our products not only provide antioxidant support but also help consumers manage stress and maintain overall health. So, embrace the power of grape seed extract and let it transform your wellness journey. References:
  1. Ma, Z. F., & Zhang, H. (2017). Phytochemical Constituents, Health Benefits, and Industrial Applications of Grape Seeds: A Mini-Review. Antioxidants (Basel, Switzerland), 6(3), 71. https://doi.org/10.3390/antiox6030071 
  2. Gupta, M., Dey, S., Marbaniang, D., Pal, P., Ray, S., & Mazumder, B. (2020). Grape seed extract: having a potential health benefits. Journal of food science and technology, 57(4), 1205–1215. https://doi.org/10.1007/s13197-019-04113-w 
  3. Feringa, H. H., Laskey, D. A., Dickson, J. E., & Coleman, C. I. (2011). The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials. Journal of the American Dietetic Association, 111(8), 1173–1181. https://doi.org/10.1016/j.jada.2011.05.015 
  4. Nallathambi, R., Poulev, A., Zuk, J. B., & Raskin, I. (2020). Proanthocyanidin-Rich Grape Seed Extract Reduces Inflammation and Oxidative Stress and Restores Tight Junction Barrier Function in Caco-2 Colon Cells. Nutrients, 12(6), 1623. https://doi.org/10.3390/nu12061623 
  5. Sochorova, L., Prusova, B., Cebova, M., Jurikova, T., Mlcek, J., Adamkova, A., Nedomova, S., Baron, M., & Sochor, J. (2020). Health Effects of Grape Seed and Skin Extracts and Their Influence on Biochemical Markers. Molecules, 25(22), 5311. https://doi.org/10.3390/molecules25225311  
  6. Li, B., Cheng, J., Cheng, G., Zhu, H., Liu, B., Yang, Y., Dai, Q., Li, W., Bao, W., & Rong, S. (2023). The effect of grape seed procyanidins extract on cognitive function in elderly people with mild cognitive impairment: A randomized, double-blind, placebo-controlled clinical trial. Heliyon, 9(6), e16994. https://doi.org/10.1016/j.heliyon.2023.e16994  
  7. Mohammad, A., Shahnaz, T., & Sorayya, K. (2020). Effect of 8 weeks’ supplementation grape seed extract on insulin resistance in iranian adolescents with metabolic syndrome: A randomized controlled trial. Diabetes & Metabolic Syndrome Clinical Research & Reviews, 15(1), 197–203. https://doi.org/10.1016/j.dsx.2020.12.028 
  8. Park, S. H., Park, T. S., & Cha, Y. S. (2008). Grape seed extract (Vitis vinifera) partially reverses high fat diet-induced obesity in C57BL/6J mice. Nutrition research and practice, 2(4), 227–233. https://doi.org/10.4162/nrp.2008.2.4.227 
  9. Ao, X., & Kim, I. (2020). Effects of grape seed extract on performance, immunity, antioxidant capacity, and meat quality in Pekin ducks. Poultry Science, 99(4), 2078–2086. https://doi.org/10.1016/j.psj.2019.12.014  
  10. Chen, B., Hung, M., Chen, J. Y., Chang, H., Yu, M., Wan, L., Tsai, F. J., Wang, T., Fu, T., & Chiu, C. (2011). Anti-allergic activity of grapeseed extract (GSE) on RBL-2H3 mast cells. Food Chemistry, 132(2), 968–974. https://doi.org/10.1016/j.foodchem.2011.11.079 
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